H2N2V1, Main, Exploration, bibRecord, 002796

Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers

Identifieur interne : 002796 ( Main/Exploration ); précédent : 002795; suivant : 002797

Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers

Auteurs : A. J. Moritz [Autriche, États-Unis] ; C. Kunz [Autriche, États-Unis] ; H. Hofman [Autriche, États-Unis] ; E. Liehl [Autriche, États-Unis] ; P. Reeve [Autriche, États-Unis, Royaume-Uni] ; H. F. Maassab [Autriche, États-Unis]

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1980.

RBID : ISTEX:6380C5E3E156D86272BAD256A722DD9E9C508623

Descripteurs français

KwdFr :
- Animaux, Basse température, Embryon de poulet, Grippe humaine (immunologie), Humains, Méthode en double aveugle, Production d'anticorps, Recombinaison génétique, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux (immunologie), Virus de la grippe A (génétique), Virus de la grippe A (immunologie).
MESH :
- génétique : Virus de la grippe A.
- immunologie : Grippe humaine, Vaccins antigrippaux, Virus de la grippe A.
- Animaux, Basse température, Embryon de poulet, Humains, Méthode en double aveugle, Production d'anticorps, Recombinaison génétique, Sous-type H3N2 du virus de la grippe A.

English descriptors

KwdEn :
- Animals, Antibody Formation, Chick Embryo, Cold Temperature, Double-Blind Method, Humans, Influenza A Virus, H3N2 Subtype, Influenza A virus (genetics), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Recombination, Genetic.
MESH :
- chemical , immunology : Influenza Vaccines.
- genetics : Influenza A virus.
- immunology : Influenza A virus, Influenza, Human.
- Animals, Antibody Formation, Chick Embryo, Cold Temperature, Double-Blind Method, Humans, Influenza A Virus, H3N2 Subtype, Recombination, Genetic.

Abstract

A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.

Url:

https://api.istex.fr/ark:/67375/HXZ-BQ8D9QRL-B/fulltext.pdf

DOI: 10.1093/infdis/142.6.857

Affiliations:

Le document en format XML

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<author><name sortKey="Reeve, P" sort="Reeve, P" uniqKey="Reeve P" first="P." last="Reeve">P. Reeve</name>
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<author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name>
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<idno type="eISSN">1537-6613</idno>
<imprint><publisher>The University of Chicago Press</publisher>
<date when="1980-12">1980</date>
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<term>Antibody Formation</term>
<term>Chick Embryo</term>
<term>Cold Temperature</term>
<term>Double-Blind Method</term>
<term>Humans</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza A virus (genetics)</term>
<term>Influenza A virus (immunology)</term>
<term>Influenza Vaccines (immunology)</term>
<term>Influenza, Human (immunology)</term>
<term>Recombination, Genetic</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Basse température</term>
<term>Embryon de poulet</term>
<term>Grippe humaine (immunologie)</term>
<term>Humains</term>
<term>Méthode en double aveugle</term>
<term>Production d'anticorps</term>
<term>Recombinaison génétique</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
<term>Vaccins antigrippaux (immunologie)</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (immunologie)</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term>
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</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Vaccins antigrippaux</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
<term>Influenza, Human</term>
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<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Antibody Formation</term>
<term>Chick Embryo</term>
<term>Cold Temperature</term>
<term>Double-Blind Method</term>
<term>Humans</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Recombination, Genetic</term>
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<term>Basse température</term>
<term>Embryon de poulet</term>
<term>Humains</term>
<term>Méthode en double aveugle</term>
<term>Production d'anticorps</term>
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<front><div type="abstract">A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.</div>
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<name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name>
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<name sortKey="Liehl, E" sort="Liehl, E" uniqKey="Liehl E" first="E." last="Liehl">E. Liehl</name>
<name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name>
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Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers

Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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